Coluracetam is a member of the racetam family and like Piracetam and Aniracetam can boost cognitive function. It has also been shown to improve memory and focus, enhance vision (making colors brighter, contrast more intense), relieve anxiety, depression and alleviate symptoms of schizophrenia.
Unlike other nootropics that influence increased production of the neurotransmitter acetylcholine, Coluracetam powder europe affects the high-affinity choline uptake system. This makes it a popular addition to choline supplements and nootropic stacks.
Improves Memory and Concentration
Coluracetam improves your memory and concentration by enhancing the high-affinity choline uptake (HACU) process in your brain. Choline is a precursor to the neurotransmitter acetylcholine, which plays an important role in memory retention and learning. Coluracetam also improves AMPA potentiation, which is a key mechanism for memory formation.
In one study, researchers administered coluracetam to rats that had been given a chemical that disrupted their cholinergic neurons. After taking the supplement for a few days, the rats demonstrated improved memory and attention. The improvements in cognition lasted even after the coluracetam was stopped.
While the bulk of research on coluracetam is on its effects on choline, it’s also shown to protect NMDA receptors against glutamate toxicity. This is a major benefit, since it helps prevent cognitive decline due to Alzheimer’s disease and traumatic brain injury. It can also boost your mood and provide some anxiolytic effects, making it useful for treating anxiety disorders such as depression.
Promotes Neurogenesis
Coluracetam is a nootropic from the racetam family and was developed in 2005 by Mitsubishi Tanabe Pharma Corporation. It was originally studied as a potential Alzheimer’s disease treatment, but it has not been approved by the FDA for any medical purposes.
Unlike piracetam, which makes ACh receptors accept acetylcholine more easily, coluracetam works by improving the high affinity choline uptake (HACU) process. This is the rate-limiting step in acetylcholine synthesis and if it’s not working properly, you can experience cognitive problems.
HACU also increases AMPA potentiation, which is the ability of neurons to absorb calcium ions and boosts cell function. This makes it possible for neurons to make and store memories more efficiently. Research has shown that it can also treat depression by decreasing glutamate toxicity. In one study, regular intake of coluracetam for 21 days led to a 20% improvement in anxiety, which was much greater than the 12% effect that valium had. This is thought to be due to a boost in acetylcholine activity.
Promotes Nerve Growth
Coluracetam powder (BCI-540, formerly MKC-231), from the racetam family, boosts cognition and improves mood in some patients. It has the potential to treat a number of mental illnesses and may help with anxiety, depression, and major depressive disorder (MDD). It can also improve spatial learning by balancing levels of acetylcholine in the brain.
This is done by enhancing the HACU process that ensures choline is taken up into neurons at a rapid rate. Then acetylcholine is synthesized and stored in the neuron terminals to be used when needed. This allows the brain to work more efficiently and reduces problems with memory and learning.
It also has the ability to inhibit glutamate cytotoxicity and increase AMPA potentiation. However, more research needs to be conducted on this. Also, it can interact with anticholinergic drugs such as antipsychotics and Parkinson’s medications. So, it’s recommended to consult a doctor before taking this nootropic.
Enhances Vision
One of the most notable coluracetam benefits is improved eyesight. This is mainly due to its ability to enhance acetylcholine levels in the brain which is involved in vision and sight. Users have reported that their eyesight is enhanced to the point where things become vivid and clearer.
Unlike aniracetam which affects acetylcholine directly, the main mechanism of action of coluracetam is through increasing high-affinity choline uptake and the conversion into acetylcholine. It has also been shown to improve a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPA) potentiation which enhances long-term memory and learning.
However, it is important to note that this supplement can interfere with drugs that interact with the cholinergic system such as Parkinson’s medications, some Benadryl, and some antipsychotics. It is therefore advised to stack it with a choline source like CDP-Choline or Alpha-GPC to avoid this issue. Aside from enhancing cognition, this nootropic has been known to alleviate depression and anxiety as well as treat irritable bowel syndrome.